Causes of Disease… Heme Synthesis 3 Aug 20177 Aug 2017 Heme, a porphyrin, is a co-factor in haemoglobin, myoglobin, cytochrome, catalase, heme peroxidase, and endothelial nitric oxide synthase. It has a complex structure with four pyrrole rings with a ferrous…
Anemia… The Erythrocyte Membrane 4 Feb 201411 Oct 2017 Compared to other cells of the body the erythrocyte, consistent with its simple functional requirements, has a simple structure. The erythrocyte delivers oxygen to tissue and aids in carriage of…
Anemia… Erythrocyte Metabolism 6 Aug 20137 Aug 2013 As erythrocytes lack mitochondria they are not able to use fats or generate energy from Krebs cycle. Though they have enzymes to synthesize glycogen the balance between synthesis and breakdown…
Anemia… Red Cell Distribution Width 1 Oct 2012 Features of peripheral smear like erythrocyte size, haemoglobinization and variability in size have long been useful in evaluation of patients with anaemia. The definitions of these parameters before the advent of…
Bone Marrow Examination… Megaloblasts 25 Jul 20123 Jan 2015 Development of erythrocytes involves coordinated changes in the nucleus and the cytoplasm of erythroid processors (see Morphology of Erythroid Precursors) . The proerythroblast is a large cell with a fine…
Transfusion Medicine Complications of Blood and Blood Product Transfusion 29 May 201226 Sep 2014 IMMUNE COMPLICATION Haemolytic transfusion reactions: Haemolysis following red cell transfusion occur in two forms. Acute haemolysis occurs within 24 hours, is more serious and usually intravascular. Delayed haemolysis occurs after…
Haematology Atlas… Normal Erythrocytes 26 May 201213 Jun 2012 Normal erythrocytes are round disks about 7.5μm in diameter.The central one third is paler than the periphery because of the discoid shape of the erythrocyte. The picture above is a 40X…
