Anemia… Treatment of Warm Antibody Type Autoimmune Haemolytic Anaemia (WAIHA) 20 Feb 201820 Feb 2018 Warm antibody type of autoimmune haemolytic anaemia (WAIHA) is characterised by anaemia, reticulocytosis, conjugated hyperbilirubinaemia with the presence of a positive anti-globulin (Coombs') test (see Diagnosis of haemolytic anaemia). It may…
Anaemia of Liver Disease… 78 year old Alcoholic With Anaemia 29 Oct 201729 Oct 2017 An 78 year old man presented with fatigue and breathlessness. Examination showed pallor. There was no icretus, clubbing, lymphadenopathy or hepatomegaly. There was mild splenomegaly. There was no history of haemoptysis,…
Anaemia of Renal Insufficiency… Anaemia of Renal Insufficiency 24 Aug 201724 Aug 2017 Richard Bright discovered the relationship of renal failure and anaemia in 1836. Anaemia of renal insufficiency is mainly results from decreased erythropoietin production and impaired supply of iron to erythroid…
Anemia… Anaemia with Thrombocytosis 8 Aug 20178 Aug 2017 A 49 year old woman presented with weakness and fatigability. On examination, other than pallor of the skin and mucosa there was no other finding. A haemogram was done that…
Causes of Disease… Heme Synthesis 3 Aug 20177 Aug 2017 Heme, a porphyrin, is a co-factor in haemoglobin, myoglobin, cytochrome, catalase, heme peroxidase, and endothelial nitric oxide synthase. It has a complex structure with four pyrrole rings with a ferrous…
Acute Lymphoblastic Leukaemia… Evaluation of Splenomegaly 17 May 201717 May 2017 The spleen is a secondary lymphoid organ that lies in intraperitoneally in the left hypochondrium, abuting the diaphragm. It spans from the 9th to 11th rib and weighs between 150-200g. Spleen…
Anemia… Oral Iron Therapy 1 May 20171 May 2017 Iron deficiency anaemia is treated by iron supplementation that may be administered orally or parenterally. Oral iron absorption is inefficient, is interfered by food and is associated with high incidence…
Anemia… Clinical Features of Megaloblastic Anaemia 2 Jul 20162 Jul 2016 Megaloblastic anaemia is a macrocytic anaemia resulting from the deficiency of vitamin B12 or folic acid characterised by the presence of megaloblasts in the bone marrow. It has haematological and neurological…
Anemia… Evolution and Spread of HbS 20 Jun 201620 Jun 2016 The gene for β globin (OMIM is present on chromosome 11 (11p15.4) along with other globin genes (ε, γ, γ and δ). This is known as the β-globin cluster .…
Anemia… Anaemia with Hyperbilirubinaemia 8 Jun 201610 Jun 2016 A 49-year-old female presented with dyspnoea on exertion of 1 month duration. Examination reviled pallor and icterus. There was no lymphadenopathy, clubbing, koilonychia, platonychia, petechiae or purpura. There was no oedema…
