MCQ – Haemoglobinopathy

Which of the following is least likely to have splenomegaly persisting to adulthood?

  1. βthalassaemia intermedia
  2. Sickle cell anaemia
  3. Sickle cell trait
  4. Sickle β+ thalassaemia

 

Which of the following is most commonly characterised by iron overload?

  1. Alpha thalassaemia
  2. β+ thalassaemia major
  3. Sickle cell disease 
  4. Hb D 

A Rh positive woman from South-east Asia delivers a neonate with hydrops fetalis. What is the likely cause?

  1. α-thalassaemia
  2. β-thalassaemia Major
  3. δ-thalassaemia
  4. Haemoglobin E diseases

Which of The following haemoglobinopathy does not give protection against malaria

  1. Sickle cell anaemia
  2. Haemoglobin C disease
  3. Beta thalassaemia
  4. Haemoglobin D

Which of the following statements about sickle cell anaemia is not true?

  1. Hemoglobin S polymerises under hypoxic conditions
  2. Hypoxia and dehydration increase the risk of sickling
  3. Haemoglobin F increases the risk of sickling
  4. Nigeria, democratic republic of Congo and India are the three countries with the highest number of patients with sickle cell anaemia

 

 

Answer 1

B. Sickle cell anaemia – Recurrent splenic infractions from early childhood result in a small fibrotic spleen

Answer 2

B. Patients with β+ thalassaemia major accumulate iron because of increased intestinal iron absorption and blood transfusion

Answer 3

A. α-thalassaemia. Barts hydrops faetalis results from a severe form of alpha thalassaemia resulting from the loss of all four alpha globin genes. This mainy seen in south east asia and Thailand.

Answer 4

D. Haemoglobin D does not protect against malaria, other haemoglobinopathies do

Answer 5

C. Haemoglobin F decreases the risk of sickling

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