Sickle Cells

Sickle Cell - 100X - IMG_0542

Sickle Cells 40X

Sickle Cell 100X - IMG_0540

Sickle Cells – 100X

Sickle Cell 100X - IMG_0538

Sickle Cells – 100X


The three photomicrographs above show sickle cells from a patients with sickle cell anemia. Sickle cell anaemia occurs because an A→T substitution in codon 6 of the β globin chain of haemoglobin. The single nucleotide polymorphism results in valine substituting for glutamic acid resulting in the formation of haemoglobin S (HbS). HbS crystallizes in hypoxic conditions resulting in sickling of erythrocytes.

Related articles
Sickle Haemoglobin and Variants

Advertisements

2 Comments

    1. The only cure for sickle cell anaemia is a allogenic stem cell transplant. This is a difficult procedure and has many side effects and is appropriate in very few sickie cell anaemia patients

      Reply

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s